Ethionamide
Ethionamide is part of a group of drugs used in the treatment of drug resistant TB called thioamides. It is used as part of treatment regimens, generally involving 5 medicines, to treat MDR and XDR TB.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 166.24 |
| Cas No. | 536-33-4 |
| Formula | C8H10N2S |
| Solubility | ≥7.65 mg/mL in DMSO |
| Chemical Name | 2-ethylpyridine-4-carbothioamide |
| SDF | Download SDF |
| Canonical SMILES | CCC1=NC=CC(=C1)C(=S)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
HepG2, Caco-2 and RAW macrophages |
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Preparation method |
The solubility of this compound in DMSO is ≥7.65mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
0.50 mM |
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Applications |
In HepG2, Caco-2, and RAW macrophages, when Ethionamide concentration is higher than 0.50 mM, it is generally toxic to cells, but when Ethionamide is loaded into microparticles, the toxicity is significantly reduced. In the presence of thermal carbonized-porous silicon (TCPSi) particles, Ethionamide exhibits a rapid metabolic process. |
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References: [1]. Vale N, Mäkilä E, Salonen J, Gomes P, Hirvonen J, Santos HA. New times, new trends for ethionamide: In vitro evaluation of drug-loaded thermally carbonized porous silicon microparticles. Eur J Pharm Biopharm. 2012 Jun;81(2):314-23. doi: 10.1016/j.ejpb.2012.02.017. Epub 2012 Mar 6. PubMed PMID: 22418076. |
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Quality Control & MSDS
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Chemical structure
