Fatostatin A
Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP), which can inhibit the activation of SREBP-1 and SREBP-2[1].
Fatostatin A (0.1-1 μM; 3 days) inhibits the androgen-independent proliferation of prostate cancer cell in a manner independent of the known IGF1 signaling pathway. Fatostatin A inhibits insulin-induced fat formation in 3T3-L1 cells[2].
Fatostatin A (30 mg/kg; 150 mL; i.p.; daily for 28 days) prevents obese ob/ob mice from increasing their weight, blood sugar, and liver fat accumulation, even if they do not control the food intake of mice[1].
References:
[1]. Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009, 16(8): 882-92.
[2]. Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003, 278(9): 7320-4.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 375.33 |
| Cas No. | 298197-04-3 |
| Formula | C18H18N2S·HBr |
| Solubility | insoluble in H2O; ≥19.76 mg/mL in DMSO; ≥5.02 mg/mL in EtOH |
| Chemical Name | 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide |
| SDF | Download SDF |
| Canonical SMILES | CCCC1=NC=CC(C2=NC(C3=CC=C(C=C3)C)=CS2)=C1.Br |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
