Heparin sodium

Animal models

Male New Zealand rabbits with a mean body weight of 2300 ± 300 g

Dosage form

2000 IU heparin

Administered by the intravenous route (i.v.)

Applications

Heparin increased both anti-factor Xa activity and activated partial thromboplastin time (aPTT). Heparin (2000 IU, i.v.) showed an AUC_0→24/kg value of 3.30 ± 0.59 IU·h^-1·mL^-1·kg^-1, with 100% absolute bioavailability. Apart from the parenteral route, heparin could also be administered by the oral route when incorporated into polymeric nanoparticles which were able to maintain the anti-Xa activity of heparin for a longer period.

Note

The technical data provided above is for reference only.

References:

1. Jiao Y, Ubrich N, Marchand-Arvier M, et al. In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation, 2002, 105(2): 230-235.