MPP dihydrochloride
- 1. Qing Wang, Fengqi Huang, et al. "The ERβ‐CXCL19/CXCR4‐NFκB pathway is critical in mediating the E2-induced inflammation response in the orange-spotted grouper (Epinephelus coioides)." J Steroid Biochem Mol Biol. 2021 Sep;212:105926. PMID: 34091027
- 2. Xiaoyu Hang, Zhenyu Zhang, et al. "Estrogen Protects Articular Cartilage by Downregulating ASIC1a in Rheumatoid Arthritis." J Inflamm Res. 2021 Mar 12;14:843-858. PMID: 33737825
| Physical Appearance | White solid |
| Storage | Store at -20°C |
| M.Wt | 542.5 |
| Cas No. | 911295-24-4 |
| Formula | C29H31N3O3·2HCl |
| Solubility | <54.25mg/ml in DMSO |
| Chemical Name | 4-(1-(4-hydroxyphenyl)-4-methyl-5-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1H-pyrazol-3(2H)-ylidene)cyclohexa-2,5-dienone dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | OC1=CC=C(C=C1)N(C(C(C=C2)=CC=C2OCCN3CCCCC3)=C/4C)NC4=C(C=C5)\C=CC5=O.Cl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Primary hippocampal cells |
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Preparation method |
The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months. |
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Reacting condition |
1 pM ~ 1 μM |
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Applications |
In primary hippocampal cells, E4 alone or in combination with MPP Dihydrochloride significantly decreased H2O2-induced LDH activity. Moreover, E4, E4 ﹢MPP Dihydrochloride or E4 ﹢MPP Dihydrochloride ﹢ PHTTP significantly increased the cell survival rate, which suggested that neither inhibition of ERα alone nor inhibition of both receptors (i.e. ERα and ERβ) blocked the E4-dependent cell survival activity. However, E4 ﹢ PHTTP (inhibition of ERβ alone) significantly down-regulated the cell survival rate. |
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References: [1]. Tskitishvili E, Pequeux C, Munaut C, Viellevoye R, Nisolle M, Nol A, Foidart JM. Estrogen receptors and estetrol-dependent neuroprotective actions: a pilot study. J Endocrinol. 2017 Jan;232(1):85-95. | |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
Related Biological Data
