Naspm trihydrochloride
Naspm trihydrochloride is a selective antagonist of Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. AMPA receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. On excitatory neurons in adult animals, two types of AMPA receptors are primarily expressed, namely heteromeric channels composed of GluR1 and GluR2 subunits (GluR1/2 receptors), as well as channels composed of GluR2 and GluR3 subunits (GluR2/3 receptors). Naspm trihydrochloride blocks AMPA receptors lacking the GluR2 subunit, with an IC50 value of 0.3 μM for GluR1 homomers.
References:
1. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Journal of the American Chemical Society, 2007, 129(16): 4902-4903.
2. Koike M, Iino M, Ozawa S. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neuroscience Research, 1997, 29(1): 27-36.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 479.91 |
| Cas No. | 1049731-36-3 |
| Formula | C22H34N4O·3HCl |
| Solubility | Soluble to 100 mM in sterile water |
| Chemical Name | N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | O=C(CC1=CC=CC2=CC=CC=C12)NCCCNCCCCNCCCN.Cl.Cl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[2] | |
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Cell lines |
Rat hippocampal neurons |
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Reaction Conditions |
0.01 ~ 10 μM Naspm trihydrochloride |
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Applications |
Naspm trihydrochloride (3 μM) selectively inhibited the strong inward rectification and Ca2+-permeable AMPA receptors expressed in type Ⅱ neurons, but showed no effect on AMPA receptors in type Ⅰ neurons. At -60 mV, Naspm trihydrochloride suppressed AMPA receptors in type Ⅱ neurons, with an IC50 value of 0.33 µM. The blocking effect of Naspm trihydrochloride on the Ca2+-permeable AMPA receptors was dose- and voltage-dependent. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Journal of the American Chemical Society, 2007, 129(16): 4902-4903. 2. Koike M, Iino M, Ozawa S. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neuroscience Research, 1997, 29(1): 27-36. |
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Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
