Piperlongumine
Catalog No.
A4455
Inducer of cell-death
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Induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53. Also inhibits the growth of spontaneous malignant breast tumors in mice. Displays little effect on normal cells. Rapidly depletes androgen receptor expression in human prostate cancer cells via a ROS-dependent, proteasome-mediated mechanism.
- 1. Di Chen, Xinyue Wei, et al. "Piperlongumine combined with vitamin C as a new adjuvant therapy against gastric cancer regulates the ROS–STAT3 pathway." J Int Med Res. 2022 Apr;50(4):3000605221093308. PMID: 35481419
- 2. Chen D, Ma Y, et al. "Two Natural Alkaloids Synergistically Induce Apoptosis in Breast Cancer Cells by Inhibiting STAT3 Activation." Molecules. 2020;25(1):216. PMID: 31948057
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 317.34 |
| Cas No. | 20069-09-4 |
| Formula | C17H19NO5 |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥10.45 mg/mL in DMSO |
| Chemical Name | 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one |
| SDF | Download SDF |
| Canonical SMILES | COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
Related Biological Data
