POM 1
POM 1, also known as sodium polyoxotungstate and sodium metatungstate, is a novel, potent inhibitor of ecto-nucleoside triphosphate diphosphohydrolases (Ecto-NTPDases). POM 1 exhibits minor selectivity for NTPDase 1 and NTPDase 3 over NTPDase 2, with Ki values being 2.58, 28.8 and 3.26 μM for NTPDase 1 (CD39), NTPDase 2 and NTPDase 3, respectively. Ecto-NTPDases capable of hydrolyzing nucleoside tri- and diphosphates are able to reduce the effective concentration of the released nucleotide, and inhibitors of Ecto-NTPDases can thus serve as valuable tools for amplifying the biological effects triggered by extracellularly released nucleotides.
References:
1. Müller CE, Iqbal J, Baqi Y, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorganic & Medicinal Chemistry Letters, 2006, 16(23): 5943-5947.
2. Wall MJ, Wigmore G, Lopatár J, et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology, 2008, 55(7): 1251-1258.
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 2986.01 |
| Cas No. | 12141-67-2 |
| Formula | H2O40Na6W12 |
| Solubility | ≥149.3 mg/mL in DMSO with ultrasonic; insoluble in EtOH; ≥65.4 mg/mL in H2O |
| SDF | Download SDF |
| Canonical SMILES | [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].O.[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O].[O-].[O-].[O-].[O-].[O-].[O-].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W].[W] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[2] | |
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Cell lines |
Cerebellar and hippocampal slices |
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Reaction Conditions |
100 μM POM 1 |
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Applications |
POM 1 was more effective than ARL 67156 (the best available Ecto-NTPDase inhibitor) at blocking ATP breakdown, but its usefulness was limited by off-target actions on synaptic transmission. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Müller CE, Iqbal J, Baqi Y, et al. Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorganic & Medicinal Chemistry Letters, 2006, 16(23): 5943-5947. 2. Wall MJ, Wigmore G, Lopatár J, et al. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology, 2008, 55(7): 1251-1258. |
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Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
