PSB 1114
Catalog No.
B7649
P2Y2 receptor agonist
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PSB 1114 is a potent and selective agonist of P2Y2 receptor with EC50 value of 0.134 μM [1].
P2Y2 receptor is a purinergic G protein-coupled receptor and is activated by ATP and UTP. P2Y2 receptor is a potential target for treatment of cystic fibrosis.
PSB 1114 is a potent and selective P2Y2 receptor agonist. PSB 1114 activated P2Y2, P2Y4 and P2Y6 with EC50 values of 0.134, 9.3 and 7.0 μM respectively and exhibited >60-fold selectivity versus P2Y6 and P2Y4 receptors [1].
Reference:
[1]. El-Tayeb A, Qi A, Nicholas RA, et al. Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. J Med Chem, 2011, 54(8): 2878-2890.
| Physical Appearance | Colourless liquid |
| Storage | Store at -20°C |
| M.Wt | 622.14 |
| Formula | C10H11F2N2Na4O13P3S |
| Solubility | <10mM in H2O |
| SDF | Download SDF |
| Canonical SMILES | FC(P([O-])([O-])=O)(P([O-])(OP([O-])(OC[C@](O1)([H])[C@](O)([H])[C@](O)([H])C1([H])N2C=CC(S)=NC2=O)=O)=O)F.[Na+].[Na+].[Na+].[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
