Terfenadine
Catalog No.
A8534
Histamine H1-receptor antagonist
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Terfenadine is a histamine H1-receptor antagonist, which blocks HERG and KATP (KIR6) channels. The IC values for Terfenadines inhibitory activity against these channels is 204nM for HERG and 1.2µM for KATP. Studies show that Terfenadine inhibits the delayed rectifier K+ in ventricular myocytes. Terfenadine is converted into its more active form, terfenadine carboxylate by the enzyme CYP3A4.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 471.67 |
| Cas No. | 50679-08-8 |
| Formula | C32H41NO2 |
| Solubility | insoluble in H2O; ≥18 mg/mL in DMSO; ≥8.06 mg/mL in EtOH with ultrasonic |
| Chemical Name | 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C)C1=CC=C(C=C1)C(CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
