TG 100801
TG100801 is a multi-kinases inhibitor. It is a pro-drug version of TG100572. [1]
TG100572 inhibits several growth factor receptors in addition to Src family kinases. TG100801 significantly inhibited laser-induced CNV in mice, and suppressed fluorescein leakage from the vasculature and retinal thickening measured by optical coherence tomography in a rat model or retinal vein occlusion. TG100801 may play as a new topically applied treatment approach for ocular neovascularization and retinal edema. The highest concentration of TG100801 was found at the front of the rat eye (conjunctiva and cornea). [1]
Reference:
1. Doukas J, Mahesh S, Umeda N et al. Topical administration of a multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. J Cell Physiol. 2008 Jul;216(1):29-37.
| Storage | Store at -20°C |
| M.Wt | 580.08 |
| Cas No. | 867331-82-6 |
| Formula | C33H30ClN5O3 |
| Synonyms | TG100801;TG-100801 |
| Solubility | Soluble in DMSO |
| Chemical Name | [4-chloro-3-[5-methyl-3-[4-(2-pyrrolidin-1-ylethoxy)anilino]-1,2,4-benzotriazin-7-yl]phenyl] benzoate |
| SDF | Download SDF |
| Canonical SMILES | CC1=C2C(=CC(=C1)C3=C(C=CC(=C3)OC(=O)C4=CC=CC=C4)Cl)N=NC(=N2)NC5=CC=C(C=C5)OCCN6CCCC6 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | TG 100801 is the prodrug of TG 100572. | |||||
| Targets | VEGFR1 | VEGFR2 | FGFR1 | Src | Fyn kinase | |
| IC50 | 2 nM | 7 nM | 2 nM | 1 nM | 0.5 nM | |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
