Cyclo (-RGDfK)
Catalog No.
A8164
Inhibitor of αvβ3 integrin
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In one study where this peptide was labeled with 125I, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. The integrin alpha(IIb)beta(3)-specific cyclic hexapeptide contains an Arg-Gly-Asp (RGD) sequence.
- 1. Alessandro Bortolami, Wei Yu, et al. "Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy." Cell Death Differ. 2023 Mar;30(3):687-701. PMID: 36207442
- 2. Yu W, Shin MR, et al. "Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling." FASEB J. 2019 Nov 2:fj201901792R. PMID: 31682765
- 3. Lee HN, Bosompra OA, et al. "RECK isoforms differentially regulate fibroblast migration by modulating tubulin post-translational modifications." Biochem Biophys Res Commun. 2019 Mar 5;510(2):211-218. PMID: 30704758
- 4. Lim C, Moon J, et al. "Cyclic RGD-conjugated Pluronic(?) blending system for active, targeted drug delivery." Int J Nanomedicine. 2018 Aug 10;13:4627-4639. PMID: 30127610
- 5. Schneider G, Suszynska M, et al. "Vitronectin in the Ascites of Human Ovarian Carcinoma Acts as a Potent Chemoattractant for Ovarian Carcinoma: Implication for Metastasis by Cancer Stem Cells[J]." Journal of Cancer Stem Cell Research, 2016, 4: e1005.
| Storage | Store at -20°C |
| M.Wt | 603.7 |
| Cas No. | 161552-03-0 |
| Formula | C27H41N9O7 |
| Synonyms | Cyclo(-Arg-Gly-Asp-D-Phe-Lys) |
| Solubility | ≥30.19 mg/mL in DMSO; insoluble in EtOH; ≥59.2 mg/mL in H2O |
| Chemical Name | 2-[(2S,5R,8S,11S)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid |
| SDF | Download SDF |
| Canonical SMILES | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | Cyclo (-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin. | |||||
| Targets | Integrin | |||||
| IC50 | ||||||
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