Vancomycin hydrochloride
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1485.72 |
| Cas No. | 1404-93-9 |
| Formula | C66H76Cl3N9O24 |
| Solubility | ≥55.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; ≥22.15 mg/mL in H2O |
| SDF | Download SDF |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Animal experiment:[1] | |
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Animal models |
C57BL/6 mice challenged with Clostridium difficile (C. difficile) strain VPI 10463 |
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Dosage form |
20 mg/kg Once daily by oral gavage for 5 days |
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Applications |
Vancomycin treatment of infected mice was associated with improved clinical, diarrhea, and histopathology scores and survival during treatment. However, after discontinuation of the drug, clinical scores and histopathology were worse in treated mice than in untreated infected controls. Decreasing the duration of vancomycin treatment from 5 days to 1 day decreased recurrence and deaths in C. difficile infection. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Warren CA, van Opstal EJ, Riggins MS, et al. Vancomycin treatment's association with delayed intestinal tissue injury, clostridial overgrowth, and recurrence of Clostridium difficile infection in mice. Antimicrobial Agents and Chemotherapy, 2013, 57(2): 689-696. |
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Quality Control & MSDS
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Chemical structure
