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Signaling Pathways

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  1. Actinomycin D
    A4448 Actinomycin D
     15 Citation
    Summary: RNA polymerase inhibitor
      ≥62.75 mg/mL
  2. Plumbagin
    A4456 Plumbagin
    Summary: Anticancer agent
  3. Bax inhibitor peptide V5
    A4461 Bax inhibitor peptide V5
    Target: Bax
    Summary: Bax inhibitor
      ≥29.35 mg/mL
  4. PRIMA-1
    A4483 PRIMA-1
    Target: p53
    Summary: BAX inhibitor
      ≥110.6 mg/mL
  5. WR 1065
    A4487 WR 1065
    Summary: P53/p21waf-1/MDM2 activator
      ≥26.7 mg/mL
  6. Mitomycin C
    A4452 Mitomycin C
     3 Citation
    Summary: Inhibits DNA synthesis,antibiotic and antitumor agent
      insoluble in H2O; insoluble in EtOH; ≥16.7 mg/mL
  7. NSC 687852 (b-AP15)
    A4453 NSC 687852 (b-AP15)
    Target: Deubiquitinating enzymes (DUBs)
    Summary: 19S regulatory particle Inhibitor
      insoluble in EtOH; insoluble in H2O; ≥20.95 mg/mL
  8. Pifithrin-μ
    A4482 Pifithrin-μ
     1 Citation
    Target: Autophagy|p53|HSP70
    Summary: Inhibitor of p53 binding and anti-apoptotic
      insoluble in H2O; ≥18.1 mg/mL
  9. Regorafenib
    A8236 Regorafenib
     4 Citation
    Target: Raf|VEGFR|PDGFR|c-Kit|RET
    Summary: Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1
      ≥25.04 mg/mL
  10. VX-765
    A8238 VX-765
     1 Citation
    Target: Caspases
    Summary: Caspase-1 inhibitor,potent and selective
      insoluble in H2O; ≥313 mg/mL

Items 1-10 of 69

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Category
  1. Caspase 10item
  2. Apoptosis Inducers 13item
  3. Bax 2item
  4. Bcl-2 Family 17item
  5. Bcl-xL 2item
  6. c-RET 4item
  7. IAP 4item
  8. KEAP1-Nrf2 3item
  9. MDM2 2item
  10. p53 11item
  11. PC-PLC 2item
  12. PKD 1 item
  13. Survivin 1 item
  14. Thymidylate Synthase 2item
  15. TNF-α 5item
Specificity
  1. Selective 41item
Reversibility
  1. Irreversible 7item
Target
  1. Caspases 9item
  2. Proteasome 1 item
  3. Histone Deacetylases (HDACs) 2item
  4. Inhibitor of apoptosis proteins (IAP) 3item
  5. Bcl-2 9item
  6. Raf 2item
  7. Aurora Kinases 1 item
  8. Bcl-xl 2item
  9. MDM2 2item
  10. VEGFR 3item
  11. PDGFR 3item
  12. c-Kit 2item
  13. RET 1 item
  14. Mcl-1 6item
  15. Thymidylate Synthase 1 item
  16. Bcr-Abl 1 item
  17. Nrf2 2item
  18. Sir2-like Family Deacetylases (Sirtuins) 1 item
  19. Deubiquitinating enzymes (DUBs) 1 item
  20. Aminopeptidases 1 item
  21. RIP kinases 1 item
  22. Topoisomerases 1 item
  23. Survivin 1 item
  24. Dehydrogenase 1 item
  25. Autophagy 1 item
  26. TRP Channel 1 item
  27. angiogenesis 1 item
  28. c-RET 1 item
  29. FPTase 1 item
  30. Bfl-1 1 item
  31. p53-MDM2 interaction 1 item
  32. p53 6item
  33. cysteine protease 1 item
  34. HDM2 ubiquitin ligase 1 item
  35. PC-PLC 2item
  36. HIV 1 item
  37. Histone Acetyltransferases (HATs) 1 item
  38. Telomerases 1 item
  39. Tyrosinases 1 item
  40. HSP70 1 item
  41. Ubiquitin E3 Ligases 1 item
  42. p21 1 item
  43. DHFR 1 item
  44. GARFT 1 item
  45. PKD 1 item
  46. MCL1 1 item
  47. Bcl-w 1 item
  48. Bax 1 item
  49. NS3/4a Proteases 1 item
Related Disease
  1. Acute Myeloid Leukemia 1 item
  2. Adrenocortical Carcinoma 1 item
  3. Autoimmune Diseases 1 item
  4. Breast Cancer 9item
  5. Cancer 43item
  6. Chronic Lymphocytic Leukemia 1 item
  7. Chronic Myeloproliferative Disorders 1 item
  8. Colon Cancer 2item
  9. Colorectal Cancer 3item
  10. Glioblastoma 4item
  11. HCV 1 item
  12. Hepatocellular Carcinoma 1 item
  13. Inflammatory Diseases 1 item
  14. Lung Cancer 2item
  15. Lymphoma 3item
  16. Melanoma 2item
  17. Multiple Myeloma 2item
  18. Myelofibrosis 1 item
  19. Myeloma 1 item
  20. Neuroblastoma 1 item
  21. Non-small Cell Lung Cancer 4item
  22. Ovarian Cancer 1 item
  23. Pain Relief 1 item
  24. Pancreatic Cancer 3item
  25. Pentacyclic Triterpenoid 1 item
  26. Prostate Cancer 5item
  27. Pulmonary Fibrosis 1 item
  28. Rheumatoid Arthritis 1 item
  29. Soft Tissue Sarcoma 1 item
  30. Testicular Cancer 1 item