Endocrinology and Hormones
There are three types of hormones based on their chemical composition: Amines (e.g. dopamine, adrenalin and noradrenalin); Steroids (e.g. estrogen, testosterone and glucocorticoids); Peptides (e.g. the peptide hormones insulin, ghrelin and vasopressin). Peptide hormones produced by secretory nervous tissue are known as neuropeptides. For example, thyroid hormone plays important parts in development, homeostasis and metabolism, while cortisol is essential for growth, nutrient supply and immune function. Moreover, the regulation of blood glucose involves several pancreatic peptide insulin and its counter regulatory hormone, glucagon, as well as cortisol, growth hormone and epinephrine.
Dysregulations in endocrine system are implicated in diseases such as Acromegaly, Cushing Syndrome, Diabetes, Dwarfism, Graves Disease, Hermaphroditism, Delayed and Precocious Puberty and Thyroid Diseases.
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B1519 Bazedoxifene HClTarget: Estrogen and Related ReceptorsSummary: Novel, non-steroidal, indole-based estrogen receptor modulator (SERM)
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B1505 EpiandrosteroneTarget: Voltage-gated Calcium Channels (CaV)Summary: steroid hormone with weak androgenic activity
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B1506 Estradiol valerateTarget: Estrogen and Related ReceptorsSummary: Estrogen receptor agonist
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B1507 EstriolTarget: Estrogen and Related ReceptorsSummary: Estrogen receptor antagonist
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B1518 Erteberel (LY500307)Target: Estrogen and Related ReceptorsSummary: ERβ agonist, potent and selective
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B1510 Medroxyprogesterone acetateTarget: Progesterone ReceptorsSummary: Steroidal progestin
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B3470 EtonogestrelTarget: Progesterone ReceptorsSummary: steroidal progestin
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B3471 MedroxyprogesteroneTarget: Progesterone ReceptorsSummary: potent progesterone receptor agonist
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A3003 MDV3100 (Enzalutamide)12 CitationTarget: Androgen ReceptorsSummary: Androgen receptor antagonist
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A4326 TAK-700 (Orteronel)2 CitationTarget: human lyaseSummary: Human 17,20-lyase inhibitor