Endocrinology and Hormones
There are three types of hormones based on their chemical composition: Amines (e.g. dopamine, adrenalin and noradrenalin); Steroids (e.g. estrogen, testosterone and glucocorticoids); Peptides (e.g. the peptide hormones insulin, ghrelin and vasopressin). Peptide hormones produced by secretory nervous tissue are known as neuropeptides. For example, thyroid hormone plays important parts in development, homeostasis and metabolism, while cortisol is essential for growth, nutrient supply and immune function. Moreover, the regulation of blood glucose involves several pancreatic peptide insulin and its counter regulatory hormone, glucagon, as well as cortisol, growth hormone and epinephrine.
Dysregulations in endocrine system are implicated in diseases such as Acromegaly, Cushing Syndrome, Diabetes, Dwarfism, Graves Disease, Hermaphroditism, Delayed and Precocious Puberty and Thyroid Diseases.
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B5421 (Z)-4-HydroxytamoxifenTarget: Estrogen and Related ReceptorsSummary: ER modulator, potent and selective
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B5455 G-14 CitationTarget: GPR30Summary: GPR30 agonist, potent and selective
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B5469 G-153 CitationTarget: GPR30Summary: GPER receptor antagonist
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B3470 EtonogestrelTarget: Progesterone ReceptorsSummary: steroidal progestin
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B3471 MedroxyprogesteroneTarget: Progesterone ReceptorsSummary: potent progesterone receptor agonist
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B6621 DAMGOSummary: μ opioid receptor agonist
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B5111 DPDPESummary: Prototypical selective δ-opioid receptor agonist peptide
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B6269 nor-Binaltorphimine dihydrochlorideSummary: κ-opioid receptor antagonist
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B6429 Naltrindole hydrochlorideSummary: δ opioid antagonist
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A1020 GnRH Associated Peptide (GAP) (1-13), humanTarget: prolactin secretion|gonadotropin releaseSummary: Inhibitor of prolactin secretion