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IκB/IKK

IKK (IκB kinase) is an enzyme complex that participates in NF-κB signaling pathway. It phosphorylates and inhibits IκB, thus leads to the activation of NF-κB. It is a target for treatment of inflammatory diseases and cancer.

A3485 IKK-2 inhibitor VIII

Summary: IKK-2 inhibitor,potent and selective

Soluble in DMSO
A3635 MRT67307 HCl

Target: TBK1|MARK1|NUAK1

Summary: SIK/TBK-1/IKKe inhibitor

≥23.25 mg/mL
A4210 Bay 11-7821 (BAY 11-7082)

1 Citation

Summary: IKK/NF-κB/TNFα inhibitor

insoluble in H2O; ≥64 mg/mL
A4217 QNZ (EVP4593)

2 Citation

Summary: Potent NF-κB inhibitor
A3248 BMS345541 hydrochloride

Target: IKK

Summary: IKK inhibitor,highly selective

insoluble in EtOH; insoluble in DMSO; ≥60 mg/mL
B1587 IMD 0354

1 Citation

Summary: IKKβ inhibitor

insoluble in H2O; ≥100.8 mg/mL
B1585 SC-514

Summary: ATP-competitive IKK-2 inhibitor, orally active

insoluble in EtOH; insoluble in H2O; ≥50.4 mg/mL
N1831 Luteolin

Target: AP-1|MMP|15-lipoxygenases

Summary: Antioxidant and free radical scavenger
N1846 Tanshinone IIA

Target: AP-1|MAGL

Summary: Antioxidant and anti-inflammatory reagent

insoluble in EtOH; insoluble in H2O; ≥3.42 mg/mL
A2604 Celastrol

Target: Proteasome

Summary: Antioxidant, anti-inflammatory and immunosuppressive agent

≥22.55 mg/mL