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PI3K

PI3K (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.

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  1. PI-103 Hydrochloride
    A3724 PI-103 Hydrochloride
    Target: PI3K|mTOR|DNA-PK
    Summary: DNA-PK/PI 3-kinase/mTOR inhibitor
      insoluble in H2O; insoluble in EtOH; ≥19.25 mg/mL
  2. VS-5584 (SB2343)
    A3927 VS-5584 (SB2343)
    Target: PI3K|mTOR
    Summary: MTOR/P13K inhibitor,potent and selective
      insoluble in H2O; ≥17.7 mg/mL
  3. CUDC-907
    A4097 CUDC-907
    Target: Histone Deacetylases (HDACs)|PI3K
    Summary: Potent PI3K/HDAC inhibitor
      ≥25.45 mg/mL
  4. GDC-0032
    B1047 GDC-0032
    Target: PI3K
    Summary: PI3Kα inhibitor
      ≥23.05 mg/mL
  5. GSK2636771
    B2186 GSK2636771
    Target: PI3K
    Summary: PIK3 inhibitor
      insoluble in H2O; insoluble in EtOH; ≥10.83 mg/mL
  6. BAY 80-6946 (Copanlisib)
    B2178 BAY 80-6946 (Copanlisib)
     1 Citation
    Target: PI3K
    Summary: PI3K inhibitor
      insoluble in DMSO; insoluble in H2O; insoluble in EtOH
  7. AS-252424
    B2180 AS-252424
    Target: Akt|PI3K
    Summary: PI3Kγ inhibitor,novel and potent
      insoluble in EtOH; insoluble in H2O; ≥30.5 mg/mL
  8. TG100713
    B2177 TG100713
    Target: PI3K
    Summary: pan-PI3K inhibitor
      soluble in DMSO
  9. NVP-BGT226
    A8488 NVP-BGT226
    Target: PI3K|mTOR
    Summary: PI3K/mTOR inhibitor,selective and novel
      insoluble in EtOH; insoluble in H2O; ≥16.28 mg/mL
  10. PF-04691502
    A8499 PF-04691502
    Target: Akt|PI3K|mTOR
    Summary: PI3K/mTOR (FRAP) inhibitor
      insoluble in H2O; insoluble in EtOH; ≥10.63 mg/mL

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