Hedgehog
Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.
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A8659 SANT-11 CitationSummary: Shh inhibitor,potent and cell-permeable -
A3021 GDC-0449 (Vismodegib)1 CitationTarget: P-glycoprotein (P-gp)|HedgehogSummary: Hedgehog antagonist,potent and selective
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A8228 PurmorphamineSummary: Hedgehog agonist
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A1615 GANT611 CitationTarget: GLISummary: GLI antagonist
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A8340 Cyclopamine1 CitationTarget: SmoothenedSummary: Hedgehog (Hh) signaling Inhibitor
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B7803 MK-4101Summary: Hedgehog (Hh) signaling pathway inhibitor
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B5837 SAGSummary: Hh and Smo agonist
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C5136 Oxy-16Summary: antagonist of hedgehog activity
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C5138 CUR 61414Summary: potent inhibitor of hedgehog-induced cellular activity
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B6812 U 18666ASummary: inhibitor of cholesterol transport and synthesis