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FLT3

FLT3 (FMS-like tyrosine kinase 3) is a cytokine receptor which belongs to the receptor tyrosine kinase class III and plays a role in cell survival, proliferation, and differentiation.

Items 11-19 of 19

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  1. Cabozantinib (XL184, BMS-907351)
    A2977 Cabozantinib (XL184, BMS-907351)
    Summary: VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor
      ≥25.08 mg/mL
  2. Ponatinib (AP24534)
    A5467 Ponatinib (AP24534)
     1 Citation
    Target: VEGFR|PDGFR|Bcr-Abl|FGFR|Src
    Summary: pan-BCR-ABL inhibitor,multi-kinase inhibitor
      ≥53.3 mg/mL
  3. Quizartinib (AC220)
    A5793 Quizartinib (AC220)
    Target: FLT3
    Summary: FLT3 inhibitor,potent and selective
      ≥28.03 mg/mL
  4. TCS 359
    A2323 TCS 359
    Summary: Potent FLT3 inhibitor
      insoluble in EtOH; insoluble in H2O; ≥9 mg/mL
  5. SU5614
    B6097 SU5614
    Summary: tyrosine kinase inhibitor
      ≥27.3 mg/mL
  6. Tandutinib (MLN518) HCl
    B7853 Tandutinib (MLN518) HCl
    Summary: FLT3 inhibitor,potent and selective
      ≥59.9 mg/mL
  7. 5'-Fluoroindirubinoxime
    B5516 5'-Fluoroindirubinoxime
    Summary: FMS-like receptor tyrosine kinase-3 (FLT3) inhibitor
      <29.53 mg/mL
  8. G-749
    A8889 G-749
    Target: Aurora Kinases|FLT3|c-RET
    Summary: FLT3 inhibitor
      ≥26.05 mg/mL
  9. UNC2025
    B8016 UNC2025
     1 Citation
    Target: MER|FLT3
    Summary: orally bioavailable dual MER/FLT3 inhibitor
      ≥23.85 mg/mL

Items 11-19 of 19

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