Spermidine trihydrochloride
Spermidine trihydrochloride is an agonist of the N-methyl-D-aspartate (NMDA) receptor. The NMDA receptor is a ligand-gated ion channel complex with multiple regulatory sites in addition to the glutamate recognition site. Spermidine binds to the polyamine modulatory site of the NMDA receptor, and has been classified as agonists at this site based on their ability to enhance the binding of MK801 (a noncompetitive antagonist of the NMDA receptor). Thus, spermidine potentially enhances the neuroprotective effect of NMDA antagonists.
References:
1. Munir M, Subramaniam S, McGonigle P. Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Research, 1993, 616(1-2): 163-170.
2. Carvalho FB, Mello CF, Marisco PC, et al. Spermidine decreases Na⁺, K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats. European Journal of Pharmacology, 2012, 684(1-3): 79-86.
3. Rao TS, Cler JA, Oei EJ, et al. The polyamines, spermine and spermidine, negatively modulate N-methyl-d-aspartate (NMDA) and quisqualate receptor mediated responses in vivo: Cerebellar cyclic GMP measurements. Neurochemistry International, 1990, 16(2): 199-206.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 254.63 |
| Cas No. | 334-50-9 |
| Formula | C7H19N3·3HCl |
| Solubility | insoluble in DMSO; insoluble in EtOH; ≥10 mg/mL in H2O |
| Chemical Name | N1-(3-aminopropyl)butane-1,4-diamine trihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | NCCCCNCCCN.Cl.Cl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[2] | |
|
Cell lines |
Hippocampal slices and homogenates from rats |
|
Reaction Conditions |
0.05 ~ 10 μM spermidine for 30 min incubation |
|
Applications |
Spermidine at the concentrations of 0.5 and 1 μM decreased Na+, K+-ATPase activity in slices, but not in homogenates. Spermidine also increased NO2 plus NO3 (NOx) levels in slices. |
| Animal experiment:[3] | |
|
Animal models |
Male Swiss-Webster mice |
|
Dosage form |
200 μg/mouse Orally |
|
Applications |
Spermidine at 200 μg/mouse did not alter the basal cGMP level in mouse cerebellum. Moreover, spermidine attenuated responses mediated through NMDA, NMDA-associated glycine receptor and quisqualate receptors. Since spermidine is widely distributed in neural and non-neural tissues, it plays a potential key role in cell differentiation and growth. |
|
Note |
The technical data provided above is for reference only. |
|
References: 1. Munir M, Subramaniam S, McGonigle P. Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Research, 1993, 616(1-2): 163-170. 2. Carvalho FB, Mello CF, Marisco PC, et al. Spermidine decreases Na⁺, K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats. European Journal of Pharmacology, 2012, 684(1-3): 79-86. 3. Rao TS, Cler JA, Oei EJ, et al. The polyamines, spermine and spermidine, negatively modulate N-methyl-d-aspartate (NMDA) and quisqualate receptor mediated responses in vivo: Cerebellar cyclic GMP measurements. Neurochemistry International, 1990, 16(2): 199-206. |
|
Quality Control & MSDS
- View current batch:
Chemical structure
