SR 3576
| Physical Appearance | Off White solid |
| Storage | Store at -20°C |
| M.Wt | 501.53 |
| Cas No. | 1164153-22-3 |
| Formula | C27H27N5O5 |
| Solubility | <50.15mg/ml in DMSO |
| Chemical Name | 3-(4-(3-(m-tolyl)ureido)-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide |
| SDF | Download SDF |
| Canonical SMILES | O=C(C1=CC(N2N=CC(NC(NC3=CC=CC(C)=C3)=O)=C2)=CC=C1)NC(C=C4OC)=CC(OC)=C4OC |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment[1]: | |
|
Cell lines |
Human ovarian cancer cisplatin-resistant SKOV3/DDP cells |
|
Preparation method |
The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
|
Reacting condition |
24 h, 2 μM |
|
Applications |
SR 3576 is a specific inhibitor of JNK3. Inhibition of JNK3 by SR 3576 exacerbates oxidative stress and suppresses autophagic flux, resulting in an increase of apoptosis induced by S1 in human ovarian cancer SKOV3/DDP cells. |
|
References: [1]. Yang X, Xiang X, Xia M, et al. Inhibition of JNK3 promotes apoptosis induced by BH3 mimetic S1 in chemoresistant human ovarian cancer cells[J]. The Anatomical Record, 2015, 298(2): 386-395. | |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
Related Biological Data
