Tyrphostin 9
Tyrphostin 9 is an inhibitor of PDGFR with IC50 value of ~2.5μM [1].
Tyrphostin 9 is generated as specific inhibitor of PDGFR in 1991. It also has inhibitory effect on the proliferation of SMC. Tyrphostin 9 potently inhibits the PDGF-dependent SMC proliferation with IC50 value of 40nM and inhibits the PDGF-dependent autophosphorylation of PDGFR with IC50 value of ~2.5μM. Besides that, Tyrphostin 9 also affects the phosphorylation of PLCγ (IC50 value of about 2.5μM) and the PDGF-dependent c-fos expression. Moreover, Tyrphostin 9 is found to be an inhibitor of EGFR with IC50 value of 460μM [1, 2].
In the rat carotid artery injury model, treatment of Tyrphostin 9 significantly reduces neointimal hyperplasia through inhibiting the tyrosine phosphorylation in injured arteries [1].
References:
[1] Levitzki A. PDGF receptor kinase inhibitors for the treatment of restenosis. Cardiovascular research, 2005, 65(3): 581-586.
[2] Levitzki A. Tyrphostins—potential antiproliferative agents and novel molecular tools. Biochemical pharmacology, 1990, 40(5): 913-918.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 282.38 |
| Cas No. | 10537-47-0 |
| Formula | C18H22N2O |
| Solubility | insoluble in H2O; ≥14.1 mg/mL in DMSO; ≥16.77 mg/mL in EtOH with ultrasonic |
| Chemical Name | 2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile |
| SDF | Download SDF |
| Canonical SMILES | CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)C=C(C#N)C#N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | Tyrphostin 9 is an inhibitor of EGFR and PDGFR with IC50 values of 460 μM and 0.5 μM， respectively. | |||||
| Targets | PDGFR | EGFR | ||||
| IC50 | 0.5 μM | 460 μM | ||||
Quality Control & MSDS
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Chemical structure
