4'-Demethylepipodophyllotoxin
Catalog No.
A3123
Anti-cancer drug
Featured Products
Description:
IC50 Value: 0.31uM(EC50 for HL60 cell, MTT assay, 48h); 0.37uM(EC50 for HepG2 cell, MTT assay, 48h) [1]
4'-demethylepipodophyllotoxin is a key intermediate compounds for the preparation of podophyllotoxin-type anti-cancer drugs.
in vitro: 4-TMP-DMEP showed strong cytotoxicity activity against the above-mentioned five tumor cell lines. The EC50s of 4-TMP-DMEP against these tumor cell lines ranged from 0.24 to 0.11 μM, which were 0.29 to 3618 times lower than that of DMEP [1].
in vivo: Treatment of animals with DMEP (until the end of the experiment), 30 min before TPA treatment, significantly reduced the tumor incidence, tumor volume and the conversion efficiency of papillomas to squamous cell carcinomas. The tumor formation and growth was also delayed by DMEP pre-treatment [2].
Clinical trial: N/A
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 400.38 |
| Cas No. | 6559-91-7 |
| Formula | C21H20O8 |
| Synonyms | 4'-O-demethylepipodophyllotoxin;4'-DMEP |
| Solubility | ≥83.33 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | 6-oxo-1H-pyrazine-3-carboxylic acid |
| SDF | Download SDF |
| Canonical SMILES | COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
