IKK-3 Inhibitor
Catalog No.
A3486
IKK-3 Inhibitor
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An IKK-3 Inhibitor. The NF-κB/Rel transcription factors, known to be involved in the regulation of pro-inflammatory cytokines and the pathogenesis of a variety of diseases, are present in the cytosol in an inactive state, complexed with inhibitory IκB proteins. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKKα and IKK-β, can also activate NF-κB. IKK-ε is expressed predominantly in immune cells, and is thought to play a role in the immune response. It is a benzimidazole analog that selectively inhibits IKK-ε with an IC50 value of 40 nM and is essentially inactive at IKK-α and IKK-β.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 469.53 |
| Cas No. | 862812-98-4 |
| Formula | C22H19N3O5S2 |
| Solubility | Soluble in DMSO |
| Chemical Name | 5-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-((2-(methylsulfonyl)benzyl)oxy)thiophene-2-carbonitrile |
| SDF | Download SDF |
| Canonical SMILES | COC1=C(OC)C=C2C(N=CN2C3=CC(OCC4=CC=CC=C4S(=O)(C)=O)=C(C#N)S3)=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
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